Endocrine Abstracts

Background: MiRNAs transported by exosomes play a role in various processes of tumorigenesis and tumor progression. They can function as oncogenes able to structurally and biologically change the tumor microenvironment (TME) therefore playing a crucial role in cell-to-cell communication during tumor development and allowing cancer cells to become invasive and disseminate from the primary site to distant locations.We aimed to identify the exosome miRNAs that may be involved in ...

Radioiodide 131I (RAI) is the therapy of choice for radioiodine-avid differentiated thyroid cancer (DTC). However, 5–15% of DTC patients become RAI refractory (RAIR), and the 10-year survival rate for metastatic disease decreases to 10%. The failure of RAI response is mainly due to the loss of thyroid differentiation, that leads to the loss of expression/function of components of iodide metabolism, first of all the Na/I symporter (NIS). The finding that the MAPK pathway i...